Synthesis of Arylidene (thio)barbituric Acid Derivatives using Bentonite as a Natural and Reusable Catalyst in Green Media
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Abstract:
Known as a Lewis acid which acts as a natural catalyst, bentonite can be used to produce several arylidene (thio) barbituric acid derivatives through conducting a Knoevenagel reaction between aromatic aldehydes and (thio) barbituric acid. Water is considered as the medium for this reaction and the results are at arange of good to excellent over a reasonable reaction time. This method is natural and economic as well as convenient to work with, while the reaction time is also short. In addition to excellent results, this method is also environment-friendly due to the use of water as solvent that broadens the domain of organic synthesis in aqueous medium.
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Journal title
volume 14 issue 2
pages 36- 47
publication date 2020-05-01
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